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HIV vaccines guide rare immune cells to make broadly neutralizing antibodies
S. Gnanakaran is in the Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, USA.
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Cynthia A. Derdeyn is in the Department of Laboratory Medicine and Pathology, Washington National Biomedical Research Center, University of Washington, Seattle, Washington 98195, USA.
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A vaccine that protects against HIV has remained out of reach since the virus was first isolated in the 1980s. Three studies published in Nature, from Guenaga et al.1, Marchitto et al.2 and Steichen et al.3, now represent an important preclinical advance towards this long-standing goal.
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Marchitto, L. et al. Nature https://doi.org/10.1038/s41586-026-10838-4 (2026).