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Brain organoids grafted into cortex-free mice will advance human brain research

Published: 10/06/2026, 12:00 AM

Marty G. Yang is in the Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095-1737, USA. Search author on: PubMed Google Scholar Aparna Bhaduri is in the Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California 90095-1737, USA. Search author on: PubMed Google Scholar Models of the brain — known as brain organoids — that are built from stem cells have transformed the study of human-specific developmental processes and disease-specific traits. But existing tools are restricted by several factors: organoids cannot mature beyond a certain point; they mostly lack interactions with other brain structures; and it is impossible to get any kind of behavioural output from them. Writing in Nature, Kaganovsky et al.1 address these limitations using an innovative experimental model: an engraftment of human brain organoids into a living mouse. Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Prices may be subject to local taxes which are calculated during checkout Article PubMed Google Scholar Article PubMed Google Scholar