// BBC HEALTH NEWS — SALUTE
First personalised cancer vaccine cuts risk of disease returning in major trial
Tony Chapman, 75, from Corby in the East Midlands was one of the 1,100 melanoma patients enrolled on the vaccine trial
A new personalised cancer vaccine given alongside a widely used immunotherapy drug has cut the risk of patients dying or their skin cancer returning by 42% in a major clinical trial.
The researchers involved say the results could mark a turning point in cancer treatment, bringing personalised medicine a step closer.
The trial also found that the new drug combination reduced the risk of melanoma, a type of skin cancer, spreading by 38% over two years compared to immunotherapy alone.
The drug manufacturers MSD and Moderna say the same approach is already being tested against other tumours, including kidney, bladder and lung cancer.
Independent cancer experts described the results as impressive but said longer-term studies were still needed to establish whether the treatment really helps most patients live longer, on average.
The new approach is aimed at cancer patients who have already had their tumour removed through surgery.
In the trial, 1,137 adults were given Keytruda, an established immunotherapy drug which helps the body's immune system find and attack cancer cells.
About two-thirds also received an experimental vaccine with the rest being given a placebo or dummy drug.
The vaccine, called Intismeran, uses the same mRNA technology as some Covid jabs.