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Molecular underpinnings of rheumatic diseases and emerging therapeutic concepts

Published: 28/10/2026, 00:00

Nature volume 658, pages 1141–1152 (2026) Cite this article Inflammatory rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and systemic lupus erythematosus represent chronic inflammatory disorders that are caused by dysregulation of innate and adaptive immune responses. Here we review current advances in our understanding of the molecular underpinnings of these diseases and discuss consequences with respect to emerging targets and treatment strategies, which are increasingly enabling more robust disease control and the first prospects of a cure for previously chronic inflammatory rheumatic diseases. This is a preview of subscription content, access via your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription Prices may be subject to local taxes which are calculated during checkout Callahan, L. F. & Pincus, T. Mortality in the rheumatic diseases. Arthritis Rheum. 8, 229–241 (1995). Article CAS Google Scholar Gabriel, S. E. & Michaud, K. Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res. Ther. 11, 229 (2009). Article PubMed PubMed Central Google Scholar